What is sidenafil?

Sildenafil (Viagra), introduced in 1998 as the first PDE5 inhibitor, is arguably the most well-known treatment for erectile dysfunction (ED).

Available exclusively as an oral tablet, Viagra also has several generic versions offered at a lower cost. It should be taken once daily as needed, typically about 30 minutes before activity. For optimal effectiveness, it is recommended to take it roughly an hour prior to sexual activity to reduce the likelihood of ED.

Common side effects include headaches, facial flushing, nasal congestion or runny nose, back pain, upset stomach, muscle aches, and blurred vision.

Pros

• Sildenafil was the first PDE5 inhibitor, with numerous studies confirming its effectiveness as early as 2002.
• It is FDA-approved.
• Only requires use as needed.
• Generic versions are cost-effective.

Cons

• May cause minor side effects, such as upset stomach or changes in vision, compared to newer alternatives.
• Requires a prescription.
• Can interact dangerously with nitrate-containing medications.