Sildenafil and Cocaine

Using cocaine and sildenafil together poses significant health risks. Cocaine, a potent stimulant, has effects that counteract those of sildenafil, which relaxes blood vessels to enhance blood flow. When combined, these substances can disrupt blood flow unpredictably, potentially leading to emergencies like stroke, cardiac arrest, or heart attack.

Cocaine elevates heart rate and blood pressure, while sildenafil's vasodilatory effects can dangerously lower blood pressure. This combination places extreme strain on the cardiovascular system, increasing oxygen demand in tissues and intensifying heart activity, which may result in cardiac distress.

Moreover, mixing cocaine and sildenafil heightens the likelihood of priapism — a painful, prolonged erection requiring urgent medical care. If untreated, priapism can cause irreversible damage to penile tissue.